The 290 new jobs include research and engineering positions, in addition to support roles.
The four-year investment will fund strategic research and development projects.
"Through this investment, our R&D teams in Ireland will design innovative high-performance and adaptive computing engines to accelerate data centre, networking, 6G communications and embedded solutions while taking a leadership position on artificial intelligence," said Ruth Cotter, senior vice president, Marketing, Communications and Human Resources at AMD.
Minister for Enterprise, Trade and Employment, Simon Coveney welcomed the new jobs, commenting, "this significant investment will not only bolster our thriving technology sector but also create long-term career opportunities for both highly experienced professionals and new graduates from engineering disciplines."
The expansion announced today was supported by the Irish government through IDA Ireland.
"This expansion further strengthens the company's presence in Ireland as a leading centre of semiconductor innovation and puts Ireland at the heart of AMD’s European research and engineering operations," said Michael Lohan, Chief Executive, IDA Ireland.