The initiative is funded by the Department of Enterprise, Trade and Employment and operated by Enterprise Ireland. Other departments involved in The Hub include Departments of Finance, Social Protection and SEAI.
The Hub will bring together information and resources on over 180 government supports from 19 different departments and State agencies which can be accessed through the online hub or by speaking to a member of the team of advisors by phone or via live chat.
The service, which is free, will make it easier for entrepreneurs to access and avail of supports such as grants, funding and advice of sectors such as retail, hospitality and tourism.
It will support small business have yet to see any government backing.
Minister Burke said: "The National Enterprise Hub is a fantastic new service which for the first time, gathers together all government supports in one place for businesses to search and access, saving our SMEs time and valuable resources in identifying the grants and measures that are relevant and available.
"The aim is to make engaging with government supports more efficient, and to increase the uptake of grants and government schemes, which will ultimately support the development and growth of Irish businesses. The National Enterprise Hub was a key element of the SME Package agreed by Government in May and I am delighted that it has now been delivered."